Fermentia LLC (Budapest, Hungary) uses Spinsplit’s SpinFlow technology for fermentation optimisation. Proteins, which are widely used for industrial and medical applications, are difficult or impossible to  be synthesized chemically. Instead, biotechnological processes are used such as recombinant fermentation. Pichia fermentation is a highly flexible, promising method for industrial use. Despite its advances, the production remains expensive, the yields low and the risk of losing a batch is high. Fermentia is a contract manufacturer of proteins as a final product by recombinant fermentation technology. Within this project with Spinsplit, the specific type of proteins production process, Pichia fermentation, was meant to be optimized. The project was implemented within the framework of EU H2020 Cloudifacturing project. Before the implementation of the novel approach with Spinsplit, Fermentia used manual sample analysis and corrective actions, including reagent addition, based on the results (‘As-Is’ solution).  However, time dependent analysis process frequently led to low product yield or serious product loss. Spinsplit Spinflow proposes a new way for bioprocess optimization via automatization as well as processing and understanding past process data.