Spinsplit proudly presents white papers and journal papers where our products were utilised for the scientific experiments.

Nanofibers in Pharma

Balogh-Weiser, D., Molnár, A., Tóth, G. D., Koplányi, G., Szemes, J., Decsi, B., Katona, G., Salamah, M., Ender, F., Kovács, A., Berkó, S., Budai-Szűcs, M., & Balogh, G. T. (2023). Combined Nanofibrous Face Mask: Co-Formulation of Lipases and Antibiotic Agent by Electrospinning Technique. Pharmaceutics, 15(4), 1174.
Balogh-Weiser, D., Németh, C., Ender, F., Gyarmati, B., Szilágyi, A., & Poppe, L. (2018). Electrospun Nanofibers for Entrapment of Biomolecules. In T. Tański, P. Jarka, & W. Matysiak (Eds.), Electrospinning Method Used to Create Functional Nanocomposites Films. InTech.
Balogh-Weiser, D., Poppe, L., Kenéz, B., Decsi, B., Koplányi, G., Katona, G., Gyarmati, B., Ender, F., & Balogh, G. T. (2022). Novel biomimetic nanocomposite for investigation of drug metabolism. Journal of Molecular Liquids, 368, 120781.
Józó, M., Simon, N., Yi, L., Móczó, J., & Pukánszky, B. (2022). Improved Release of a Drug with Poor Water Solubility by Using Electrospun Water-Soluble Polymers as Carriers. Pharmaceutics, 14(1), 34.
Kazsoki, A., Palcsó, B., Alpár, A., Snoeck, R., Andrei, G., & Zelkó, R. (2022). Formulation of acyclovir (core)-dexpanthenol (sheath) nanofibrous patches for the treatment of herpes labialis. International Journal of Pharmaceutics, 611, 121354.
Kazsoki, A., Palcsó, B., Omer, S. M., Kovacs, Z., & Zelkó, R. (2022). Formulation of Levocetirizine-Loaded Core–Shell Type Nanofibrous Orally Dissolving Webs as a Potential Alternative for Immediate Release Dosage Forms. Pharmaceutics, 14(7), 1442.
Kazsoki, A., Farkas, A., Balogh-Weiser, D., Mancuso, E., Sharma, P. K., Lamprou, D. A., & Zelkó, R. (2020). Novel combination of non-invasive morphological and solid-state characterisation of drug-loaded core-shell electrospun fibres. International Journal of Pharmaceutics, 587, 119706.
Kovács, A., Kazsoki, A., Démuth, B., Szirányi, B., Madarász, J., Süvegh, K., & Zelkó, R. (2020). Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers. Pharmaceutics, 12(4), 385.
Németh, K., Kazsoki, A., Visnovitz, T., Pinke, B., Mészáros, L., Buzás, E. I., & Zelkó, R. (2022). Nanofiber formation as a promising technology for preservation and easy storage of extracellular vesicles. Scientific Reports, 12(1), 22012.
Palcsó, B., Kazsoki, A., Herczegh, A., Ghidán, Á., Pinke, B., Mészáros, L., & Zelkó, R. (2022). Formulation of Chlorine-Dioxide-Releasing Nanofibers for Disinfection in Humid and CO2-Rich Environment. Nanomaterials, 12(9), 1481.
Sipos, E., Kósa, N., Kazsoki, A., Szabó, Z.-I., & Zelkó, R. (2019). Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs. Pharmaceutics, 11(8), 417.
Tóth, G. D., Kazsoki, A., Gyarmati, B., Szilágyi, A., Vasvári, G., Katona, G., Szente, L., Zelkó, R., Poppe, L., Balogh-Weiser, D., & Balogh, G. T. (2021). Nanofibrous Formulation of Cyclodextrin Stabilized Lipases for Efficient Pancreatin Replacement Therapies. Pharmaceutics, 13(7), 972.
Tóth, G. D., Kállai-Szabó, N., Lengyel, M., Süvegh, K., Ender, F., Katona, G., Kazsoki, A., Zelkó, R., Antal, I., Balogh, G. T., & Balogh-Weiser, D. (2023). Nanoformulation of lipase from Porcine pancreas by electrospinning as a novel alternative for enzyme-based per os therapies. Journal of Molecular Liquids, 389, 122819.
Yi, L., Luo, S., Cui, L., Budai-Szűcs, M., Móczó, J., & Pukánszky, B. (2022). Processes taking place during the preparation and use of electrospun PLA fibers and their effect on controlled drug release. Journal of Thermal Analysis and Calorimetry, 147(23), 13191–13199.

Other nanofiber applications

Hegedus, K., Ender, F., & Plesz, B. (2022). Controlled Deposition of Perovskite Thin Layer with Electrospraying for Solar Cells. 2022 18th Biennial Baltic Electronics Conference (BEC), 1–5.
Józó, M., Várdai, R., Hegyesi, N., Móczó, J., & Pukánszky, B. (2021). Poly-ε-Caprolactone/Halloysite Nanotube Composites for Resorbable Scaffolds: Effect of Processing Technology on Homogeneity and Electrospinning. Polymers, 13(21), 3772.
Koplányi, G., Sánta-Bell, E., Molnár, Z., Tóth, G. D., Józó, M., Szilágyi, A., Ender, F., Pukánszky, B., Vértessy, B. G., Poppe, L., & Balogh-Weiser, D. (2021). Entrapment of Phenylalanine Ammonia-Lyase in Nanofibrous Polylactic Acid Matrices by Emulsion Electrospinning. Catalysts, 11(10), 1149.
Koplányi, G., Bell, E., Molnár, Z., Katona, G., Lajos Neumann, P., Ender, F., Balogh, G. T., Žnidaršič‐Plazl, P., Poppe, L., & Balogh‐Weiser, D. (2023). Novel Approach for the Isolation and Immobilization of a Recombinant Transaminase: Applying an Advanced Nanocomposite System. ChemBioChem, 24(7), e202200713.
Pardy, T., Joemaa, R., Ender, F., Rang, T., Hegedus, K., & Balogh-Weiser, D. (2020). Polymer Nanofiber Deposition in Lab-on-a-Chip Devices By Electrospinning. 2020 17th Biennial Baltic Electronics Conference (BEC), 1–4.

Flow chemistry applications

Balogh, G. T., Decsi, B., Krammer, R., Kenéz, B., Ender, F., Hergert, T., & Balogh-Weiser, D. (2022). Effect of Binding Linkers on the Efficiency and Metabolite Profile of Biomimetic Reactions Catalyzed by Immobilized Metalloporphyrin. Metabolites, 12(12), 1269.
Balogh-Weiser, D., Decsi, B., Krammer, R., Dargó, G., Ender, F., Mizsei, J., Berkecz, R., Gyarmati, B., Szilágyi, A., Tőtős, R., Paizs, C., Poppe, L., & Balogh, G. T. (2020). Magnetic Nanoparticles with Dual Surface Functions—Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors. Nanomaterials, 10(12), 2329.
Decsi, Krammer, Hegedűs, Ender, Gyarmati, Szilágyi, Tőtős, Katona, Paizs, Balogh, Poppe, & Balogh-Weiser. (2019). Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor. Micromachines, 10(10), 668.
Ender, F., Hegedus, K., Cseko, R., & Poppe, A. (2022). Built-in Thermal Test as a Pre-Integrated Architecture. 2022 45th International Spring Seminar on Electronics Technology (ISSE), 1–5.
Gal, C. A., Barabás, L. E., Bartha Vári, J.-H., Moisă, M. E., Balogh-Weiser, D., Bencze, L. C., Poppe, L., Paizs, C., & Toșa, M. I. (2021). Lipase on carbon nanotubes – an active, selective, stable and easy-to-optimize nanobiocatalyst for kinetic resolutions. Reaction Chemistry & Engineering, 6(12), 2391–2399.
Hamidović, M., Ender, F., & Springer, A. (2020). A Novel Enzymatic Microreactor: Towards Transforming the Pharmaceutical Industry. In A. Badnjevic, R. Škrbić, & L. Gurbeta Pokvić (Eds.), CMBEBIH 2019 (pp. 303–308). Springer International Publishing.
Hegedus, K., Hantos, G., Pardy, T., & Ender, F. (2020). In-situ Thermal Performance Monitoring of Pharma 4.0 Flow Bioreactors. 2020 26th International Workshop on Thermal Investigations of ICs and Systems (THERMINIC), 1–4.
Imarah, A. O., Silva, F. M. W. G., Bataa, N., Decsi, B., Balogh-Weiser, D., & Poppe, L. (2023). Magnetically agitated continuous-flow tube reactors with aspartate ammonia-lyase immobilized on magnetic nanoparticles. Reaction Chemistry & Engineering, 8(6), 1250–1259.
Palovics, P., & Rencz, M. (2018). Simulation of the magnetic nanoparticle filling procedure of microchambers. 2018 Symposium on Design, Test, Integration & Packaging of MEMS and MOEMS (DTIP), 1–5.
Pálovics, P., Ender, F., & Rencz, M. (2018). Geometric optimization of microreactor chambers to increase the homogeneity of the velocity field. Journal of Micromechanics and Microengineering, 28(6), 064002.
Pálovics, P., Ender, F., & Rencz, M. (2018). Towards the CFD model of flow rate dependent enzyme-substrate reactions in nanoparticle filled flow microreactors. Microelectronics Reliability, 85, 84–92.
Silva, F. M. W. G., Imarah, A. O., Takács, O., Tuba, L., & Poppe, L. (2023). Scalability of U-Shape Magnetic Nanoparticles-Based Microreactor–Lipase-Catalyzed Preparative Scale Kinetic Resolutions of Drug-like Fragments. Catalysts, 13(2), 384.

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